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Anti-TGF-b1 Antibody (3D9)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | P01137 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse IgG1κ |
| Clone Names | 3D9 |
| Calculated MW | 44325 Da |
| Gene ID | 7040 |
|---|---|
| Application & Usage | WB: HepG2 cell lysate |
| Other Names | Transforming growth factor beta-1, TGF-beta-1, TGFB |
| Target/Specificity | TGF-b1 |
| Antibody Form | Liquid |
| Appearance | Colorless liquid |
| Formulation | In phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol and 0.02% sodium azide. |
| Handling | The antibody solution should be gently mixed before use. |
| Reconstitution & Storage | -20 °C |
| Background Descriptions | |
| Precautions | Anti-TGF-b1 Antibody (3D9) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TGFB1 (HGNC:11766) |
|---|---|
| Synonyms | TGFB |
| Function | Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. |
| Cellular Location | [Latency-associated peptide]: Secreted, extracellular space, extracellular matrix |
| Tissue Location | Highly expressed in bone (PubMed:11746498, PubMed:17827158). Abundantly expressed in articular cartilage and chondrocytes and is increased in osteoarthritis (OA) (PubMed:11746498, PubMed:17827158). Colocalizes with ASPN in chondrocytes within OA lesions of articular cartilage (PubMed:17827158) |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
TGF-β1 (transforming growth factor-beta) is a multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. It also stimulates sustained production of collagen through the activation of CREB3L1 by regulated intramembrane proteolysis.
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